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Complexes formed by CXCL4–DNA–anti-CXCL4 antibodies are more effective than CXCL4–DNA complexes at stimulating pDCs. Purified pDCs were treated as indicated (huDNA at 5µg/mL) and their expression of CD38 (IFN-induced gene), as well as IFN-α release, were detected by flow cytometry and ELISA, respectively. p values by Wilcoxon’s test are reported. Results are cumulative data of two independent experiments performed in triplicate.
