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. 2020 Jul 17;21(14):5064. doi: 10.3390/ijms21145064

Table 2.

Structures, chemical type and bioactivities of mixed CB1/CB2 agonists.

Synthetic Cannabinoids Chemical Type Ki (nM)/CB EC50 (nM)/CB Bioactivity
Inline graphic
(a)
HU-210		 Classical 0.0608~0.730/CB1
0.170~0.524/CB2 [66]		 0.0702/CB1 [71]
NA/CB2		 Analgesic [53];
neuroprotective [72,73]
Inline graphic
(b)
CP-55,940		 Nonclassical 0.500~5.00/CB1
0.690~2.80/CB2 [66]		 0.0462~31.0/CB1 [24,71,74]
NA/CB2		 Anti-nociceptive, anti-emetic [53]
Inline graphic
(c)
WIN-55,212-2		 Amino-alkylindole 1.89~123/CB1
0.280~16.2/CB2 [66]		 5.50~3000/CB1 [71,74,75,76,77,78]
NA/CB2		 Analgesic, anti-inflammatory [53];
neuroprotective [79]
Inline graphic
(d)
Nabilone		 Classical 1.84/CB1
2.19/CB2 [66]		 NA Analgesic, antiemetic, anti-inflammatory [53];
neuroprotective [80,81]

Ki: binding constant; EC50: half-maximal effective concentration; NA: not available.