Skip to main content
. 2020 Jul 17;21(14):5064. doi: 10.3390/ijms21145064

Table 4.

Structures, chemical type and bioactivities of CB2-selective agonists.

Synthetic Cannabinoids Chemical Type Ki (nM)/CB EC50 (nM)/CB2 Bioactivity
Inline graphic
(a)
JWH-133		 Classical 677/CB1
3.40/CB2 [104]		 63.0 [105] Attenuating neurodegenerative and spatial memory impairment [27]; improving cerebral infarction [106];
anti-inflammatory,
ameliorating sepsis [107];
anti-cancer [53];
anti-nociceptive [108];
protective effects on renal ischemia-reperfusion injury [109] and against cardiotoxicity [110]
Inline graphic
(b)
JWH-015		 Amino-alkylindole 383/CB1
13.8/CB2 [104]		 NA Attenuating neurodegenerative,
neuroprotective [106]; immunomodulatory,
anti-inflammatory [53];
anti-nociceptive [111];
anti-cancer [112];
anti-obesity [25]
Inline graphic
(c)
PM-226		 Classical >40,000/CB1
12.8/CB2 [95]		 38.7 [95] Neuroprotective [95];
anti-neuroinflammatory [78]
Inline graphic(d)
HU-308		 Nonclassical >10,000/CB1
22.7/CB2 [66]		 5.57 [23] Anti-convulsant, neuroprotective [106]; anti-inflammatory [96,97];
anti-nociceptive [96];
anti-dyskinesia [98];
osteoprotective [97];
alleviating septic lung injury [113]
Inline graphic
(e)
GW-405833		 Amino-alkylindole 4772/CB1
3.92/CB2 [24] 		0.650 [24] Anti-nociceptive,
anti-inflammatory [99];
protective effects on acute liver injury [114]
Inline graphic
(f)
L-759,633		 Classical 1043, 15850/CB1
6.40, 20.0/CB2 [66]		 8.10 [115] Analgesic [53]
Inline graphic
(g)
L-759,656		 Classical 529~>20000/CB1
11.8~57.0 [66]		 3.10 [115] Analgesic [53]

Ki: binding constant; EC50: half-maximal effective concentration; NA: not available.