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. 2020 Jul 13;21(14):4956. doi: 10.3390/ijms21144956

Figure 2.

Figure 2

(a) Representative survival curves of MDA-MB-231 and MCF-7 cells (scrambled, sc) and their integrin β1-knockdown (ITGB1-kd) mutants on collagen type 1 (COL1) in the presence of DDR1-inhibitor 7rh for 72 h. The nontoxic concentration of 1 µM, used for adhesion studies in (c,d) is marked. (b) Statistical analysis of survival pEC50 of DDR1-inhibitor 7rh in MDA-MB-231 and MCF-7 scrambled and ITGB1-kd cells in the presence and absence of COL1. Data represent means ± SEM of at least n = 11 biological replicates. (c,d) Adhesion of MDA-MB-231 cells (c) and MCF-7 cells (d) and their ITGB1-kd mutants on COL1 in the presence or absence of DDR1-inhibitor 7rh. Data represent means ± SEM of n = 6 different biological replicates. Statistical analysis was performed via unpaired t-test (* p < 0.05; ** p < 0.01; *** p < 0.001).