Figure 5.

The impact of DDR1- or MAPK-inhibitors on the survival of MDA-MB-231 and MCF-7 cells with mitoxantrone in combinatorial approaches. The ERK1/2-inhibitor SCH772984 (a,b) and DDR1-inhibitor 7rh (c,d) were applied at increasing concentrations in dependence of collagen type 1 (COL1) in scrambled (sc) and integrin β₁-knockdown (ITGB1-kd) cells. The detected increased value of pEC₅₀ (n = 3) indicates a decrease of EC₅₀ values. Statistical analysis was performed via unpaired t-test (* p < 0.05, n = at least 3 biological samples).