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. 2020 Jun 10;215(4):1153–1169. doi: 10.1534/genetics.120.303378

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Copyright © 2020 Garge et al.

Available freely online through the author-supported open access option.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Human septins differentially rescue meiotic and mating roles of the yeast CDC10. (A) Mating rescue assay for BY4741 cdc10Δ. (B) All assayed human septins expressing strains can mate with BY4742, whereas the empty vector containing BY4741 cdc10Δ fails to rescue the mating defect caused by deleting CDC10. Plates were imaged after 3 days of incubation on SC-Lys-Met, (C) and (D) depict differential replaceability of human septin splice forms, Hs-SEPT6 and Hs-SEPT10, respectively. The top panels demonstrate the heterozygous diploid deletion mutant segregation assay for the assayed isoforms while the bottom panels show the sequence alignment of the variation across the canonical (red) and tissue-specific (blue) isoforms tested for both Hs-SEPT6 and Hs-SEPT10.