Table 9.

Green chemistry metrics for the synthesis of dihydropyrimidinones/-thiones 7.

entry	reactants		product	AE (%)	E-factora	PMIb	Curzon’s RMEc (%)	gRMEd (%)
	Ar	5/6
1	phenyl: 2a	5	7a	88	45.254	46.254	85	2.2
2	4-methylphenyl: 2b	5	7b	88	43.373	44.373	84	2.3
3	4-methoxyphenyl: 2e	5	7c	89	41.036	42.036	85	2.4
4	3,4-dimethoxyphenyl: 2f	5	7d	90	37.924	38.924	85	2.6
5	3-hydroxyphenyl: 2r	5	7e	89	43.550	44.550	85	2.2
6	2-hydroxyphenyl: 2h	5	7f	89	44.953	45.953	82	2.2
7	4-nitrophenyl: 2l	5	7g	89	39.770	40.770	84	2.5
8	4-fluorophenyl: 2m	5	7h	89	43.220	44.220	85	2.3
9	4-chlorophenyl: 2n	5	7i	89	40.311	41.311	85	2.4
10	3-bromophenyl: 2s	5	7j	90	36.254	37.254	84	2.7
11	2-furanyl: 2p	5	7k	87	50.760	51.760	78	1.9
12	2-thienyl: 2q	5	7l	88	46.600	47.600	81	2.1
13	phenyl: 2a	6	7m	89	43.045	44.045	85	2.3
14	4-methylphenyl: 2b	6	7n	89	41.341	41.341	85	2.4
15	4-methoxyphenyl: 2e	6	7o	90	39.213	40.213	86	2.5
16	4-nitrophenyl: 2l	6	7p	90	37.978	38.978	85	2.6
17	4-chlorophenyl: 2n	6	7q	90	38.685	39.685	86	2.5

^aE-factor = ^minputs^e − mass of the target product (^m7) − mass of the recovered materials/^m7. ^bPMI = (^minputs − mass of the recovered materials)/^m7 or 1 + E-factor. ^cCurzon’s RME = ^m7/^m2 + ^m 4 + ^m5/6 or yield × AE × 1/SF; SF = 1. ^dgRME = 100⋅(^m7/(^minputs − mass of the recovered materials)) or 100⋅(1/(1 + E-factor)). ^eminputs = ^m2 + ^m4 + ^m5/6 + ^mS + ^mC + ^mWPM + ^mpurification materials (PM).