Table 2.
Obesity-associated methylation markers newly identified in the current study.
| CpG ID | Chrom-osome (hg19) | Position | HGNC Symbol | Discovery (n = 450) p-Value |
Replication (n = 759) p-Value |
Replication (n = 759) p-Value (adj. T2D) |
T2DM (n = 1534) p-Value (adj. BMI) |
EWAS Catalog 1 (p < 0.05) |
EWAS Atlas 2 (p < 0.05) |
GWAS Catalog 3 (Disease Associated SNP within ± 100 kb at the CpG Site) |
|---|---|---|---|---|---|---|---|---|---|---|
| cg27589809 * | 3 | 50650410 | CISH | 1.69 × 10−8 | 1.61 × 10−2 | 1.48 × 10−2 | 8.31 × 10−1 | Triglycerides, Phospholipids to total lipids ratio, High-density lipoprotein cholesterol, Age, smoking, HIV infection | smoking | Waist-to-hip ratio adjusted for BMI, Height, Eosinophil counts |
| cg17075888 * | 7 | 95225339 | PDK4 | 4.75 × 10−6 | 1.10 × 10−8 | 1.02 × 10−4 | 2.30 × 10−13 | Body Mass Index (rs6465468, reported gene: ASB4), Metabolite levels | ||
| cg20560869 | 12 | 52447054 | NR4A1 | 1.44 × 10−6 | 3.45 × 10−3 | 1.56 × 10−2 | 5.89 × 10−1 | Metabolite levels, Lung function, neutrophil eosinophil counts, Red blood cell count, Mean corpuscular hemoglobin, Interleukin-13 levels |
1 EWAS Catalog (http://www.ewascatalog.org/), 2 EWAS Atlas (https://bigd.big.ac.cn/ewas), 3 GWAS Catalog (https://www.ebi.ac.uk/gwas/). * These CpG markers are shown in Figure S6.