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. 2020 Jul 15;21(14):4992. doi: 10.3390/ijms21144992

Figure 1.

Figure 1

In vivo examination of tumor initiation, spreading, survival and response to treatment in SCID mice IB-injected with SKOV3-M SKOV3-E and SKOV3-E+M cells. (A) Whole body representative bioluminescence images of the emerging tumors and metastatic lesions in SCID mice 59 days, 67 days, 73 days and 130 days post-injection IB of SKOV3-M, SKOV3-E and SKOV3-E+M cells. (B) Survival plots for phase 1 mice IB-injected with SKOV3-M, SKOV3-E and Mix cells. (C) Survival plots for phase 2 mice IB-injected with SKOV3-M and SKOV3-E cells, followed by treatment with carboplatin. Asterisks represent the number of sacrificed mice at each step according to the survival time, as indicated in Table 1; see also Section 4.3.5 for details.