Figure 1.
Overall structure of representative β-lactamases from A, B, C, and D classes (adapted from reference 92 with permission). (a) Class A SHV-1 (sulfhydryl reagent variable-1); (b) class B IMP-1 (imipenem-resistant Pseudomonas-1); (c) class C (AmpC (ampC β-lactamase); (d) class D OXA-1 (oxacillinase-1). Active sites of the serine-β-lactamases are colored yellow, and the metallo-β-lactamase zinc ions are shown as gray spheres.
