Table 1.
Expression levels of DEGs associated with cell migration/motility, which are upregulated in AGS cells in response to H. pylori infection but experience less, or no upregulation, in infected cells pretreated with ASTX. The expression level of each gene is reported as the read count normalized to the log2 value.
| Gene ID | Normalized (log2) Read Count | Encoded Protein | |||
|---|---|---|---|---|---|
| None | HP | ASTX | ASTX + HP | ||
| ARF4 | 7.424 | 8.152 | 8.192 | 6.187 | ADP-ribosylation factor 4 |
| CCL20 | 0.116 | 2.928 | 0.000 | 2.179 | Chemokine C-C motif ligand 20 |
| CDC42 | 9.142 | 9.921 | 9.389 | 6.982 | Cell division control protein 42 homolog |
| CXCL1 | 1.005 | 5.432 | 1.348 | 4.080 | Chemokine C-X-C motif ligand 1 |
| CXCL2 | 2.008 | 5.274 | 2.124 | 4.697 | Chemokine C-X-C motif ligand 2 |
| CXCL3 | 2.023 | 5.557 | 2.193 | 4.950 | Chemokine C-X-C motif ligand 3 |
| FAT1 | 7.348 | 8.019 | 8.158 | 5.615 | FAT atypical cadherin 1 |
| FUT8 | 6.201 | 7.140 | 7.199 | 6.646 | Fucosyltransferase 8 alpha 1,6 fucosyltransferase |
| GSK3A | 7.385 | 8.294 | 8.267 | 8.362 | Glycogen synthase kinase 3 alpha |
| ITGA1 | 1.946 | 2.266 | 1.831 | 1.728 | Integrin alpha 1 |
| IL8 | 0.704 | 7.118 | 0.341 | 6.954 | Interleukin 8 |
| MET | 5.712 | 6.961 | 6.059 | 6.022 | Met proto-oncogene |
| NDE1 | 5.108 | 5.734 | 5.819 | 5.165 | Nude neurodevelopment protein 1 |
| PIK3CB | 5.937 | 7.222 | 6.233 | 4.757 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| PKN2 | 4.999 | 5.727 | 5.828 | 4.947 | Protein kinase N2 |
| PLCG1 | 6.315 | 6.806 | 6.962 | 6.451 | Phospholipase C gamma-1 |
| RND1 | 3.343 | 4.082 | 3.228 | 3.647 | Rho family GTPase 1 |
| ROCK1 | 4.122 | 4.820 | 4.957 | 4.123 | Rho-associated coiled-coil containing protein kinase 1 |
| SEMA7A | 2.916 | 3.803 | 3.406 | 2.948 | Semaphoring 7A GPI membrane anchor |
| SLC9B2 | 2.137 | 2.614 | 2.601 | 2.130 | Solute carrier family 9 subfamily B2 |
| TNFRSF10B | 6.533 | 7.260 | 6.763 | 3.900 | Tumor necrosis factor receptor superfamily member 10b |