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Lesions induced by the HPV16 early genes were analyzed histologically (H&E, 200×). (a) Dorsal tongue. Normal oral mucosa (HPV− mouse, Group 1); (b) Dorsal tongue. Hyperplastic changes in the oral mucosa (HPV+ mouse, Group 3). Note the increased cellularity of the basal layers and normal epithelial differentiation. (c) Dorsal tongue. Squamous cell carcinoma (HPV+ mouse, Group 3). Note the intense cell pleomorphism and disrupted epithelial architecture.
