Figure 5.

Effect of SP-AS overexpression on the antiproliferative activity of miR-125a and let-7e. HuH-7 cells were transfected with miRNA mimics and their antiproliferative activity was evaluated with or without ectopic expression of SP-AS by MTT assays. Cell growth of cells transfected with control molecules (parental vector, V and unrelated miRNA mimic, Ctrl-miRNA) was set to 100; data are reported as mean ± s.d. of replicate analyses. p values at Student’s t-test between the indicated experimental groups were * or ^# p < 0.05; ** or ^## p < 0.01.