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. Author manuscript; available in PMC: 2020 Aug 5.
Published in final edited form as: Exp Neurol. 2018 Jul 12;308:111–119. doi: 10.1016/j.expneurol.2018.07.005

Fig. 4.

Fig. 4.

Zonisamide reduces the expression of gp91phox in microglia activated with MPTP. (A) mRNA expression of gp91phox in the striatum. All values were expressed as mean ± SEM from 5 animals per group. * indicates significant difference from control and # indicates significant differences from MPTP + Saline when compared with MPTP + zonisamide (p < 0.05). (B) immunolabeling of microglia and gp91phox in the striatum. Microglia were label with anti-Iba1 antibody (red) and expression of gp91phox was visualized by immunolabeling with anti-gp91phox antibody (green) at 12 h MPTP (12.5 mg/kg, s.c.) exposure with or without zonisamide (20 mg/kg, i.p. every 4 h × 3) administration. Scale bar = 20 μM.