Table 2.
Cardiolipin (CL) and phosphatidylcholine (PC) binding sites on molecular surfaces of CTI and CTII determined by AutoDock computation. Amino acid residues shaded gray represent the surface area in CTI where binding sites of CL and PC overlap, thus these residues represent a common lipid binding site both for CL and PC.
Amino Acid Residues on the Molecular Surfaces of CTII and CTI that Bind to CL and PC | ||||
---|---|---|---|---|
# | CTII + CL | CTII + PC | CTI + CL | CTI + PC |
1 | K23, R36 | K44, S45, K50, C53 | K18, K35, R36, C38 | K35, C38 |
2 | K23 | K18, K35, C38 | K12, K35 | Y22, R36, C38 |
3 | K5, K12, K35 | K35 | L9, Y22, C38 | |
4 | K5, K18, K35 | |||
Total number of binding sites for CL and PC available on CTII |
Total number of binding sites for CL and PC available on CTI |
|||
7 (4 CL + 3 PC) | 4 (3 CL + 1 PC) |