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. Author manuscript; available in PMC: 2020 Aug 5.
Published in final edited form as: Clin Cancer Res. 2017 May 22;23(17):5091–5100. doi: 10.1158/1078-0432.CCR-16-2540

Figure 3. OXPHOS up-regulation in premalignant lesion biopsies.

Figure 3.

(A) The mean baseline OCR/ECAR ratio measured in human bronchial biopsies cultures from PMLs (pink, n=6) was 2.5 fold higher than the biopsies of normal airway epithelium (gray n=6) (p=0.035). (B) Bioenergetic studies testing mitochondrial function demonstrate PMLs (pink) have a significantly (~1.5 fold) higher maximal respiration (p=0.022). Error bars in A and B represent standard error of the mean. (C&D) Mitochonrial enumeration by FACS analysis of MitoTraker GFP suggests increased OCR is not reliant on increase mitochondria as the difference in GFP per cell was not significant (p=0.150). (E) Representative images of TOMM22 and COX IV staining in which expression of both proteins is increased in low and moderate dysplastic lesions in both human and NTCU-mouse PMLs. (Magnification 400X)