Table 1.
Demographic and clinical characteristics stratified by premalignant lesion status.
| Factor | Overall (n=82) | No Lesions (n=25) | Lesions (n=50) | P* |
|---|---|---|---|---|
| Age | 62.9 (7.2) | 64.5 (5.8) | 62.2 (8.0) | 0.16 |
| Male | 54/82 (65.9) | 16/25 (64) | 35/50 (70) | 0.61 |
| Current smoker | 40/82 (48.8) | 11/25 (44) | 25/50 (50) | 0.81 |
| Pack-years | 47.3 (15.7) | 47.6 (17.9) | 47.2 (15.2) | 0.93 |
| FEV1% Predicted | 82.5 (18.6) | 84.5 (17.9) | 81.7 (19.2) | 0.54 |
| FEV1/FVC Ratio | 71.2 (7.9) | 73.4 (7.4) | 69.6 (8.1) | 0.05 |
| COPD (FEV1%<80 & FEV1/FVC<70) | 24/82 (29.3) | 5/25 (20) | 17/50 (34) | 0.28 |
| Histology | <0.001 | |||
| Normal | 12/82 (14.6) | 12/25 (48) | ||
| Hyperplasia | 13/82 (15.9) | 13/25 (52) | ||
| Metaplasia | 7/82 (8.5) | |||
| Mild Dysplasia | 35/82 (42.7) | 35/50 (70) | ||
| Moderate Dysplasia | 12/82 (14.6) | 12/50 (24) | ||
| Severe Dysplasia | 3/82 (3.7) | 3/50 (6) |
Data are means (SD) for continuous variables and proportions with percentages for dichotomous variables. P* values are for the comparison of subjects with and without premalignant lesions. Two sample t-tests were used for continuous variables: Fisher’s exact test was used for categorical variables.