Table 5.
Results from Gelling Time and Gel Depot Collapse Time Study
| Code | Gelling components in NTM-PNLC-GEL (%) |
Gelling time | Depot collapse time | Firmness (g) | Work of adhesion (g-s) | ||
|---|---|---|---|---|---|---|---|
| Guar gum | Boric acid | Carbopol 940 | |||||
| B1 | 0.2 | 0.4 | 0.1 | (−) | NA | NA | NA |
| B2 | 0.2 | 0.4 | 0.4 | (+) | Depot until >12 h | 7.36 ± 2.86 | 21.54 ± 1.52 |
| B3 | 0.1 | 0.4 | 0.1 | (−) | NA | NA | NA |
| B4 | 0.1 | 0.4 | 0.4 | (+) | Depot until >12 h | 10.32 ± 0.28 | 23.59 ± 3.04 |
| B5 | 0.1 | 0.5 | 0.1 | (−) | NA | NA | NA |
| B6 | 0.1 | 0.5 | 0.4 | (+) | Depot until >12 h | 11.30 ± 1.37 | 23.41 ± 4.31 |
| B7 | 0.2 | 0.5 | 0.1 | (−) | NA | NA | NA |
| B8 | 0.2 | 0.5 | 0.4 | (+) | Depot until >12 h | 8.42 ± 3.79 | 20.87 ± 2.18 |
(−), Does not form a gel depot and instantaneously collapses in STF. (+), Forms a gel depot immediately (<1 min).
STF, simulated tear fluid.