. 2020 Jul 24;36(6):410–420. doi: 10.1089/jop.2019.0140

Table 6.

Precorneal Tear Pharmacokinetics Parameters Obtained for Gelling System Containing Natamycin Loaded Polyethylene Glycol Nanolipid Carriers and Natacyn (5%)

Test formulations		NTM-PNLC-GEL	NTM-PNLC	Natacyn
Dose		0.3 mg	0.3 mg	5 mg
PK parameter	Units	0.3 mg	0.3 mg	5 mg
AUC_0–t	μg/μL × h	1.15 ± 0.02	0.58 ± 0.01^a	2.72 ± 0.17^b
Dose normalized AUC_0–t	(μg/μL × h)/mg	3.83 ± 0.06	1.93 ± 0.03^a	0.54 ± 0.03^b
T_0.5	h	2.82 ± 0.23	0.93 ± 0.14^a	2.78 ± 0.85
C_max	μg/μL	2.57 ± 0.09	1.37 ± 0.06^a	3.00 ± 0.18^b
Dose normalized C_max	(μg/μL)/mg	8.57 ± 0.3	4.56 ± 0.2^a	0.6 ± 0.03^b
MRT_0–∞	h	2.16 ± 0.26	1.09 ± 0.21^a	1.56 ± 0.32

^{^a}

Statistically significant difference between NTM-PNLC-GEL and NTM-PNLC at P < 0.05.

^{^b}

Statistically significant difference between NTM-PNLC-GEL and Natacyn (5%) at P < 0.05.

AUC, area under curve; C_max, maximum concentration; MRT, mean residence time; PK, pharmacokinetics; T_0.5, half-life.