TABLE 2.

The most relevant and least relevant signaling pathways of each coronavirus‐entity category

Class	Likely pathway	Z score	Unlikely pathway	Z score
C0	PKCθ signaling in T lymphocytes	1.5782	Toll‐like receptor signaling	−1.7195
C1	AMPK signaling	5.1816	TGF‐β signaling	−4.0841
C2	Extrinsic prothrombin activation pathway	4.3314	Melanocyte development and pigmentation signaling	−3.8316
C3	Renin‐angiotensin signaling	5.6100	AMPK signaling	−4.4763
C4	April mediated signaling	3.2382	Neuregulin signaling	−2.4121
C5	Melanocyte development and pigmentation signaling	3.7887	Extrinsic prothrombin activation pathway	−3.9823
C6	Leukocyte extravasation signaling	2.3615	Pancreatic adenocarcinoma Siganling	−2.3694
C7	Role of BRCA1 in DNA damage response	4.6871	NF‐κB signaling	−4.8545
C8	PKCθ signaling in T lymphocytes	1.9902	VDR_RXR activation	−2.6143
C9	Toll‐like receptor signaling	4.2000	Role of BRCA1 in DNA damage response	−2.5017
C10	April mediated signaling	4.3113	TGF‐β signaling	−3.5853
C11	Acute phase response signaling	2.5066	Renin‐angiotensin signaling	−3.2492
C12	ATM signaling	2.7020	PKCθ signaling in T lymphocytes	−1.9846
C13	Retinoic acid mediated apoptosis signaling	2.6069	Interferon signaling	−1.8953
C14	ATM signaling	2.9244	PKCθ signaling in T lymphocytes	−1.9667
C15	AMPK signaling	1.9142	Leukocyte extravasation signaling	−2.4233
C16	Role of BRCA1 in DNA damage response	3.1033	Colorectal cancer metastasis signaling	−3.1033
C17	Production of nitric oxide and reactive oxygen species in macrophages	3.1398	mTOR signaling	−2.8893
C18	Extrinsic prothrombin activation pathway	1.8215	Intrinsic prothrombin activation pathway	−1.5680
C19	Role of NFAT in regulation of the immune response	2.0089	CD40 signaling	−2.2696
C20	April mediated signaling	2.3687	Aryl hydrocarbon receptor signaling	−1.5471
C21	NRF2‐mediated oxidative stress response	1.4679	CD40 signaling	−2.4042
C22	Toll‐like receptor signaling	2.2825	Melanocyte development and pigmentation signaling	−1.6007
C23	ATM signaling	2.5518	mTOR signaling	−1.8228
C24	Melanocyte development and pigmentation signaling	2.1700	Aryl hydrocarbon receptor signaling	−2.1700
C25	Extrinsic prothrombin activation pathway	1.9825	IL‐22 signaling	−1.7638
C26	mTOR signaling	2.7449	Aryl hydrocarbon receptor signaling	−1.7790
C27	AMPK signaling	2.4033	Intrinsic prothrombin activation pathway	−1.7579
C28	NRF2‐mediated oxidative stress response	2.0846	PKCθ signaling in T lymphocytes	−1.3415
C29	TGF‐β signaling	2.4379	Ephrin A signaling	−2.0030
C30	Role of NFAT in regulation of the immune response	2.1383	Leukocyte extravasation signaling	−1.8524
C31	Role of NFAT in regulation of the immune response	1.7979	Neuregulin signaling	−1.4467