TABLE 4.
The signaling pathways enriched by 119 CSHGs
| KEGG_PATHWAY | Count | % | p value | Bonferroni | Benjamini | FDR |
|---|---|---|---|---|---|---|
| Part 1. Virus related pathways | ||||||
| ptr05162:Measles | 18 | 11% | 1.05E‐13 | 1.38E‐11 | 1.38E‐11 | 1.22E‐10 |
| ptr05164:Influenza A | 19 | 11% | 7.05E‐13 | 9.30E‐11 | 4.65E‐11 | 8.23E‐10 |
| ptr05160:Hepatitis C | 15 | 9% | 2.30E‐10 | 3.04E‐08 | 7.60E‐09 | 2.69E‐07 |
| ptr05161:Hepatitis B | 11 | 7% | 7.37E‐06 | 9.72E‐04 | 1.22E‐04 | 8.61E‐03 |
| ptr05169:Epstein–Barr virus infection | 6 | 4% | 9.87E‐03 | 7.30E‐01 | 9.58E‐02 | 1.09E+01 |
| ptr05168:Herpes simplex infection | 14 | 8% | 2.73E‐07 | 3.60E‐05 | 6.00E‐06 | 3.18E‐04 |
| Part 2. Immune functions | ||||||
| ptr04620:Toll‐like receptor signaling pathway | 15 | 9% | 6.78E‐12 | 8.95E‐10 | 2.98E‐10 | 7.92E‐09 |
| ptr04062:Chemokine signaling pathway | 16 | 10% | 9.91E‐10 | 1.31E‐07 | 2.62E‐08 | 1.16E‐06 |
| ptr04060:Cytokine‐cytokine receptor interaction | 13 | 8% | 2.80E‐06 | 3.69E‐04 | 5.28E‐05 | 3.27E‐03 |
| ptr04622:RIG‐I‐like receptor signaling pathway | 7 | 4% | 1.41E‐04 | 1.84E‐02 | 2.06E‐03 | 1.64E‐01 |
| ptr04623:Cytosolic DNA‐sensing pathway | 6 | 4% | 7.45E‐04 | 9.37E‐02 | 9.79E‐03 | 8.66E‐01 |
| ptr04630:Jak–STAT signaling pathway | 7 | 4% | 6.11E‐03 | 5.54E‐01 | 7.09E‐02 | 6.90E+00 |
| ptr04668:TNF signaling pathway | 6 | 4% | 7.61E‐03 | 6.35E‐01 | 8.06E‐02 | 8.53E+00 |