Table 3.
Pharmacokinetic parameters of WV, Snake Venom Metalloproteases (SVMPs) and Snake Venom Serine Proteases (SVSPs) following intravenous injection in G1.
| Parameter | WV | SVMP | SVSP |
|---|---|---|---|
| Administration route | I.V. | I.V. | I.V. |
| Dose (mg) | 1.04 | 0.27 | 0.38 (±0.00) |
| tz (h) | 48 | 48 | 40.00 (±6.93) |
| k10 (1/h) | 1.91 (±0.44) | 2.26 (±0.42) | 0.81 (±0.14) |
| k12 (1/h) | 3.25 (±0.36) | 2.40 (±0.49) | 0.69 (±0.58) |
| k21 (1/h) | 1.61 (±0.46) | 2.68 (±0.38) | 1.27 (±1.78) |
| t1/2 α (h) | 0.11 (±0.02) | 0.11 (±0.02) | 0.45 (±0.28) |
| t1/2 β (h) | 1.52 (±0.49) | 0.75 (±0.10) | 4.06 (±3.28) |
| C0 (ng/mL) | 97.88 (±57.79) | 21.34 (±10.72) | 28.61 (±6.82) |
| V1 (l) | 13.14 (±6.65) | 14.40 (±5.80) | 13.77 (±2.93) |
| CL1 (l/h) | 25.73 (±13.81) | 34.10 (±18.26) | 11.24 (±3.68) |
| V2 (l) | 25.47 (±7.70) | 12.86 (±5.55) | 16.67 (±11.93) |
| CL2 (l/h) | 43.11 (±21.83) | 34.19 (±15.90) | 10.10 (±9.96) |
| AUC 0-t (ng × h/mL) | 55.76 (±42.98) | 10.17 (±7.35) | 36.03 (±10.75) |
| AUC 0-∞ (ng × h/mL) | 55.77 (±43.00) | 10.32 (±7.23) | 36.19 (±10.79) |
| AUMC (ng × h2/mL) | 110.10 (±116.87) | 9.66 (±8.59) | 112.39 (±67.40) |
| MRT (h) | 1.69 (±0.55) | 0.86 (±0.17) | 2.93 (±1.47) |
| Vss (l) | 38.61 (±13.92) | 27.27 (±11.29) | 30.43 (±12.36) |
| F0-t | 1 | 1 | 1 |
| F0-∞ | 1 | 1 | 1 |
tz, time of last analytically quantifiable concentration; k10, elimination rate constant; k12, transfer rate constant from central to peripheral compartment; k21, transfer rate constant from peripheral to central compartment; t1/2 α, distribution half-life; C0, initial venom concentration; t1/2 β, elimination half-life; V1,central volume of distribution; CL1, systemic clearance; V2, peripheral volume of distribution; CL2, rapid distribution; AUC 0-t, area under the concentration-time curve from zero up to a definite time; AUC 0-∞, area under the concentration-time curve from zero to infinity; AUMC, area under the first moment of the concentration-time; MRT, mean residence time; Vss, apparent volume of distribution at equilibrium determined after intravenous administration; F0-t, fraction of the administered dose systemically available; F0-∞, fraction of the administered dose systemically available. The pharmacokinetics (PK) parameters were calculated from the data from the three sheep that make up each group.