Table 6.
Comparison of all 63 cell properties of IHC-confirmed PV-INs, SST-INs, and VIP-INs recorded at the current threshold (ct), twice current threshold (2*ct:), and the depolarizing current that evoked maximum firing frequency (max AP)
| Group | PV IN | SST IN | VIP IN | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| # | Property | Mean | SEM | Median | MAD | Mean | SEM | Median | MAD | Mean | SEM | Median | MAD |
| 1 | RMP (mV) | –66.4 | 1.20 | –67.2 | 2.30 | –62.2 | 1.10 | –63.0 | 4.10 | –59.8 | 0.90 | –59.8 | 2.50 |
| 2 | Rm (MΩ) | 159 | 10.5 | 157 | 29.3 | 414 | 31.0 | 389 | 108 | 653 | 38.7 | 616 | 148 |
| 3 | current threshold (ct: pA) | 165 | 11.0 | 160 | 40.0 | 54.3 | 6.40 | 40.0 | 20.0 | 24.0 | 1.90 | 20.0 | 0.00 |
| 4 | ct: AHP amplitude (mV) | –22.8 | 0.90 | –22.4 | 2.00 | –21.2 | 1.00 | –20.0 | 3.50 | –14.3 | 0.70 | –13.4 | 2.40 |
| 5 | ct: AHP latency (ms) | 1.88 | 0.09 | 1.80 | 0.28 | 4.91 | 1.11 | 3.58 | 0.46 | 4.30 | 0.17 | 4.17 | 0.56 |
| 6 | ct: max AP rise (mV/ms) | 243 | 11.5 | 263 | 17.2 | 180 | 7.10 | 184 | 28.1 | 161 | 6.60 | 154 | 32.0 |
| 7 | ct: max AP decay (mV/ms) | –127 | 6.40 | –134 | 21.9 | –65.0 | 2.70 | –66.4 | 9.90 | –47.6 | 1.70 | –45.3 | 4.70 |
| 8 | ct: AP half-width (ms) | 0.71 | 0.03 | 0.67 | 0.09 | 1.20 | 0.04 | 1.19 | 0.09 | 1.60 | 0.04 | 1.59 | 0.12 |
| 9 | ct: AP threshold (mV) | –37.5 | 1.20 | –37.2 | 2.60 | –33.4 | 0.70 | –34.2 | 2.80 | –33.3 | 0.70 | –33.4 | 2.30 |
| 10 | ct: AP amplitude (mV) | 67.6 | 1.70 | 68.3 | 4.00 | 69.5 | 1.60 | 70.6 | 6.60 | 72.4 | 1.00 | 72.4 | 4.10 |
| 11 | ct: AP rise/decay ratio | 1.92 | 0.04 | 1.86 | 0.11 | 2.83 | 0.12 | 2.79 | 0.41 | 3.42 | 0.12 | 3.25 | 0.36 |
| 12 | ct: AP threshold/AP amp. | –0.55 | 0.01 | –0.56 | 0.03 | –0.48 | 0.01 | –0.49 | 0.02 | –0.46 | 0.01 | –0.47 | 0.03 |
| 13 | ct: AP rise/ AP half-width | 362 | 27.7 | 395 | 90.8 | 158 | 9.70 | 162 | 29.3 | 105 | 6.80 | 99.2 | 23.0 |
| 14 | 2xct: # AP | 67.3 | 4.40 | 71.0 | 13.0 | 22.5 | 2.30 | 20.5 | 7.00 | 14.9 | 1.00 | 14.5 | 3.50 |
| 15 | 2xct: latency to first AP (ms) | 7.70 | 0.80 | 7.70 | 1.40 | 36.4 | 4.60 | 31.3 | 14.0 | 37.3 | 4.40 | 33.4 | 14.0 |
| 16 | 2xct: AHP amplitude (mV) | –17.0 | 0.80 | –16.7 | 2.60 | –18.6 | 0.90 | –17.9 | 3.80 | –13.4 | 0.80 | –13.3 | 2.30 |
| 17 | 2xct: AHP latency | 1.80 | 0.07 | 1.78 | 0.24 | 3.33 | 0.16 | 3.10 | 0.44 | 4.00 | 0.12 | 4.03 | 0.36 |
| 18 | 2xct: max AP rise (mV/ms) | 253 | 10.7 | 270 | 30.5 | 182 | 8.60 | 187 | 21.1 | 160 | 6.00 | 159 | 27.3 |
| 19 | 2xct: max AP decay (mV/ms) | –125 | 5.20 | –130 | 12.8 | –67.0 | 2.90 | –67.9 | 7.10 | –49.2 | 1.50 | –49.4 | 4.70 |
| 20 | 2xct: AP half-width (ms) | 0.77 | 0.03 | 0.73 | 0.10 | 1.16 | 0.04 | 1.13 | 0.10 | 1.55 | 0.04 | 1.53 | 0.12 |
| 21 | 2xct: AP threshold (mV) | –41.6 | 1.00 | –43.1 | 2.50 | –34.7 | 0.70 | –35.2 | 1.50 | –34.3 | 0.70 | –34.4 | 1.90 |
| 22 | 2xct: AP amplitude (mV) | 70.3 | 1.40 | 70.9 | 2.00 | 69.6 | 1.50 | 70.6 | 5.50 | 72.3 | 1.00 | 72.1 | 3.30 |
| 23 | 2xct: AP rise/decay ratio | 2.00 | 0.00 | 2.00 | 0.10 | 2.80 | 0.10 | 2.70 | 0.30 | 3.30 | 0.10 | 3.20 | 0.30 |
| 24 | 2xct: AP thresh/AP ampl | –0.59 | 0.01 | –0.61 | 0.02 | –0.50 | 0.01 | –0.51 | 0.02 | –0.47 | 0.01 | –0.48 | 0.04 |
| 25 | 2xct: AP rise/ AP half-width | 345 | 23.0 | 372 | 63.5 | 168 | 13.2 | 166 | 43.1 | 108 | 6.20 | 103 | 21.9 |
| 26 | 2xct: amp 1st/2nd AP | 1.05 | 0.01 | 1.05 | 0.02 | 1.06 | 0.01 | 1.04 | 0.02 | 1.11 | 0.01 | 1.09 | 0.05 |
| 27 | 2xct: amp 2nd/3rd AP | 1.01 | 0.00 | 1.01 | 0.01 | 1.02 | 0.00 | 1.02 | 0.01 | 1.02 | 0.01 | 1.01 | 0.01 |
| 28 | 2xct: amp 1st /last AP | 1.13 | 0.02 | 1.13 | 0.05 | 1.15 | 0.02 | 1.12 | 0.06 | 1.26 | 0.04 | 1.19 | 0.09 |
| 29 | 2xct: initial instant frequency (Hz) | 92.7 | 5.30 | 86.0 | 18.1 | 33.0 | 3.20 | 30.2 | 9.00 | 32.5 | 2.30 | 31.4 | 8.70 |
| 30 | 2xct: adaptation (Hz) | 25.4 | 2.90 | 24.0 | 9.30 | 10.9 | 1.70 | 10.4 | 4.30 | 17.7 | 2.70 | 19.2 | 9.70 |
| 31 | 2xct: ISI ratio | 0.73 | 0.03 | 0.74 | 0.05 | 0.69 | 0.03 | 0.70 | 0.09 | 0.49 | 0.06 | 0.44 | 0.19 |
| 32 | 2xct: mean of first 2 ISI (ms) | 12.2 | 0.80 | 11.9 | 2.00 | 43.7 | 5.10 | 34.9 | 10.7 | 38.2 | 2.50 | 34.3 | 6.80 |
| 33 | 2xct: SD of first 2 ISI (ms) | 1.00 | 0.10 | 1.00 | 0.50 | 4.80 | 1.10 | 3.00 | 1.70 | 7.60 | 1.30 | 5.50 | 4.00 |
| 34 | 2xct: change of ISI durationfrom 1st to 2nd AP (ms) | 1.50 | 0.20 | 1.40 | 0.70 | 6.80 | 1.60 | 4.30 | 2.40 | 3.90 | 2.60 | 6.40 | 6.10 |
| 35 | 2xct: change of instant frequencyfrom 1st to 2nd AP pair (Hz) | –10.6 | 1.20 | –10.4 | 3.70 | –5.00 | 1.10 | –4.00 | 2.10 | –4.80 | 2.00 | –6.70 | 5.30 |
| 36 | 2xct: Cv2:all | 0.05 | 0.02 | 0.03 | 0.01 | 0.08 | 0.01 | 0.06 | 0.02 | 0.23 | 0.03 | 0.21 | 0.11 |
| 37 | 2xct: Cv2-1st AP | 0.05 | 0.02 | 0.03 | 0.01 | 0.07 | 0.01 | 0.05 | 0.02 | 0.23 | 0.03 | 0.16 | 0.10 |
| 38 | 2xct: Cv2-1st/2nd AP | 0.05 | 0.02 | 0.03 | 0.01 | 0.07 | 0.01 | 0.04 | 0.02 | 0.23 | 0.03 | 0.17 | 0.11 |
| 39 | Max AP: # AP | 93.4 | 5.20 | 97.0 | 14.0 | 37.3 | 2.30 | 37.0 | 9.50 | 23.4 | 1.50 | 22.5 | 6.50 |
| 40 | Max AP: latency to first AP (ms) | 4.00 | 0.40 | 3.10 | 0.80 | 11.2 | 0.90 | 11.6 | 3.50 | 21.7 | 4.10 | 13.4 | 4.70 |
| 41 | Max AP: AHP amplitude (mV) | –12.7 | 0.80 | –13.4 | 3.40 | –15.4 | 0.90 | –15.3 | 3.60 | –11.4 | 0.90 | –11.4 | 3.00 |
| 42 | Max AP: AHP latency (ms) | 1.77 | 0.07 | 1.73 | 0.29 | 2.90 | 0.12 | 2.78 | 0.33 | 3.75 | 0.12 | 3.73 | 0.41 |
| 43 | Max AP: max AP rise (mV/ms) | 269 | 14.6 | 277 | 25.4 | 178 | 10.1 | 178 | 26.1 | 158 | 6.70 | 152 | 28.9 |
| 44 | Max AP: max AP decay (mV/ms) | –127 | 6.80 | –127 | 19.5 | –66.6 | 3.30 | –66.4 | 7.00 | –48.9 | 1.90 | –46.9 | 3.90 |
| 45 | Max AP: AP half-width (ms) | 0.84 | 0.03 | 0.81 | 0.09 | 1.14 | 0.04 | 1.16 | 0.13 | 1.54 | 0.04 | 1.51 | 0.11 |
| 46 | Max AP: AP threshold (mV) | –43.4 | 1.40 | –44.3 | 4.30 | –34.7 | 0.80 | –35.1 | 1.60 | –33.8 | 0.60 | –34.0 | 2.00 |
| 47 | Max AP: AP amplitude (mV) | 70.0 | 1.40 | 70.8 | 2.40 | 67.5 | 1.40 | 67.7 | 4.80 | 70.7 | 0.80 | 70.7 | 3.10 |
| 48 | Max AP: AP rise/decay ratio | 2.12 | 0.04 | 2.06 | 0.11 | 2.68 | 0.07 | 2.71 | 0.27 | 3.25 | 0.09 | 3.23 | 0.32 |
| 49 | Max AP: AP thresh/AP amp | –0.62 | 0.01 | –0.64 | 0.02 | –0.51 | 0.01 | –0.51 | 0.02 | –0.48 | 0.01 | –0.48 | 0.04 |
| 50 | Max AP: AP rise/AP half-width | 335 | 26.5 | 335 | 64.8 | 166 | 15.1 | 158 | 38.2 | 107 | 7.20 | 100 | 21.0 |
| 51 | Max AP: amp 1st/2nd AP | 1.11 | 0.00 | 1.11 | 0.02 | 1.14 | 0.02 | 1.12 | 0.04 | 1.22 | 0.02 | 1.22 | 0.12 |
| 52 | Max AP: amp 2nd/3rd AP | 1.04 | 0.00 | 1.04 | 0.01 | 1.04 | 0.01 | 1.03 | 0.01 | 1.05 | 0.01 | 1.05 | 0.03 |
| 53 | Max AP: amp 1st /last AP | 1.37 | 0.03 | 1.35 | 0.10 | 1.42 | 0.03 | 1.41 | 0.09 | 1.48 | 0.04 | 1.48 | 0.18 |
| 54 | Max AP: initial instant frequency (Hz) | 139 | 6.30 | 140 | 17.1 | 71.7 | 4.20 | 71.0 | 15.8 | 58.1 | 4.70 | 57.9 | 24.5 |
| 55 | Max AP: adaptation (Hz) | 50.2 | 2.80 | 48.9 | 8.80 | 38.3 | 3.20 | 37.0 | 10.9 | 36.5 | 4.50 | 38.1 | 19.5 |
| 56 | Max AP: ISI ratio | 0.60 | 0.00 | 0.70 | 0.00 | 0.50 | 0.00 | 0.50 | 0.10 | 0.50 | 0.10 | 0.30 | 0.10 |
| 57 | Max AP: Mean of first 2 ISI (ms) | 8.10 | 0.50 | 7.70 | 0.90 | 16.6 | 1.10 | 15.2 | 3.20 | 26.3 | 2.80 | 21.4 | 7.70 |
| 58 | Max AP:SD of first 2 ISI (ms) | 0.70 | 0.10 | 0.60 | 0.10 | 1.70 | 0.20 | 1.50 | 0.70 | 6.00 | 1.50 | 3.60 | 1.70 |
| 59 | Max AP: change of ISI durationfrom 1st to 2nd AP (ms) | 1.00 | 0.10 | 0.90 | 0.20 | 2.10 | 0.30 | 2.00 | 0.90 | 5.70 | 2.40 | 4.30 | 2.70 |
| 60 | Max AP: change of instantaneous frequency from 1st to 2nd AP pair (Hz) | –15.6 | 1.10 | –16.2 | 3.60 | –9.80 | 1.30 | –9.20 | 3.60 | –14.9 | 2.80 | –16.2 | 6.70 |
| 61 | Max AP: Cv2:all | 0.03 | 0.00 | 0.03 | 0.01 | 0.07 | 0.01 | 0.06 | 0.02 | 0.18 | 0.03 | 0.11 | 0.05 |
| 62 | Max AP: Cv2-1st AP | 0.03 | 0.00 | 0.02 | 0.01 | 0.07 | 0.01 | 0.06 | 0.02 | 0.17 | 0.03 | 0.10 | 0.05 |
| 63 | Max AP: Cv2-1st/2nd AP | 0.03 | 0.00 | 0.02 | 0.01 | 0.07 | 0.01 | 0.05 | 0.02 | 0.17 | 0.03 | 0.10 | 0.05 |
Cell property values are given as means and their SEM and medians and their median absolute deviation (MAD). Cell features are sorted according to the radar plots in Figure 12.