FIG. 5.
Total amount of FP measured in mouse lung after a single intratracheal instillation of 10 μg of FP formulated as free drug, MAPs or MPPs with similar particle size, drug loading, and in vitro drug release profile. Error bars indicate standard error of the mean (n = 6). Symbol (*) indicates statistically significant difference from the free drug group (P < 0.05; ANOVA). The inset shows test article characteristics: hydrodynamic diameter (Z-Ave D), drug loading, and time to release 90% of the drug load in an in vitro release test (T90). Reprinted from Popov et al., Copyright 2016, with permission from Elsevier.55 FP, fluticasone propionate; MAPs, mucoadhesive particles.