FIG. 9.
Corneal levels of LE after administration of various LE formulations to rabbits as a single topical dose (50 μL of 0.5% suspension). (A) Administration of LE-CP or LE-MPP (both 240 nm in particle size as measured by the average hydrodynamic diameter). (B) Administration of LE-MPP (240 nm) or LE-Micro (particle size >1 μm). All data are shown as mean ± SEM (n = 6 eyes). Statistical analysis was performed by using the Holm-Sidak method and multiple t-tests; P values are shown on graphs. Republished with permission of Schopf et al., Copyright 2012 ARVO; permission conveyed through Copyright Clearance Center, Inc.57 LE, loteprednol etabonate.