The study methodology involved four consecutive phases: a content analysis; academic review; expert consultation; and curriculum development. The content analysis phase included an in-depth review of literature pertaining to international antimicrobial stewardship curriculum, and antimicrobial stewardship in South Africa. The academic review phase was conducted to determine the extent to which antimicrobial stewardship is currently included in undergraduate pharmacy programs in South African schools of pharmacy. The expert consultation phase established input from actively practicing antimicrobial stewardship professionals on the roles of and knowledge required by newly qualified pharmacists to function effectively in antimicrobial stewardship. The collation of the findings from the first three phases of the study occurred during the fourth and final study phase: the curriculum development phase. The curriculum development phase ran concurrently with the first three study phases, with the curriculum being developed throughout the study as a result of the incorporation of findings from the various study phases.