Table 1.

Infection prophylaxis guideline for chimeric antigen receptor T cell patients at Memorial Sloan Kettering Cancer Center.

	Recommended agent	Duration
Antiviral prophylaxis	Acyclovira 400 mg orally twice daily	Commence with chemotherapy and continue for at least 6 months post-CAR T infusion
Anti-Pneumocystis prophylaxisb	Trimethoprim/Sulfamethoxazole 1 double-strengh tablet orally three times a week OR, if allergic or intolerant, Aerosolized pentamidine 300 mg monthly	Commence with chemotherapy and continue for 3 months post-CAR T infusion Consider extending duration beyond 3 months with persistent lymphopenia (CD4 < 200 cells/µL)
Antifungal prophylaxis	Fluconazolea 200 mg orally daily	Commence with chemotherapy and continue until neutrophil recovery (ANC > 500 cells/µL for at least 3 days)
Antifungal prophylaxis for patients at high risk for mold infection (e.g., prednisone >20 mg for >2 weeks or equivalent)	Voriconazolea,c 200 mg orally twice daily

CAR chimeric antigen receptor, ANC absolute neutrophil count.

^aProphylaxis was converted to an intravenous formulation if patient was unable to tolerate oral intake.

^bFor patients unable to take sulfa or pentamidine, dapsone 100 mg daily or atovaquone 1500 mg daily were alternatives.

^cVoriconazole was switched to micafungin 100 mg daily 48 h prior to and restarted 48 h after cyclophosphamide conditioning.