Table 5.

Baseline features of lesion status in the gastric mucosa of patients with AG and without Helicobacter pylori infection stratified by MTHFR C677T genotype

	Genotypes				C allele dominance
	CC n = 31	CT n = 69	TT n = 28	P	CC + CT n = 100	TT n = 28	P
Lesions in biopsies
Incisura
yes	10 (32%)	30 (43%)	18 (64%)	0.04	40 (40%)	18 (64%)	0.02
no	21 (68%)	39 (57%)	10 (36%)		60 (60%)	10 (36%)
Antrum
yes	28 (90%)	62 (90%)	21 (75%)	0.15	90 (90%)	21 (75%)	0.06
no	3 (10%)	7 (10%)	7 (25%)		10 (10%)	7 (25%)
Corpus
yes	1 (3%)	5 (7%)	5 (18%)	0.17	6 (6%)	5 (18%)	0.22
no	30 (97%)	64 (93%)	23 (82%)		94 (94%)	23 (82%)
Atrophy
Absent/Mild	19 (61%)	43 (62%)	12 (43%)	0.19	62 (62%)	12 (43%)	0.07
Moderate/Severe	12 (39%)	26 (38%)	16 (57%)		38 (38%)	16 (57%)
IM
Absent/Mild	14 (45%)	34 (49%)	6 (21%)	0.04	48 (48%)	6 (21%)	0.01
Moderate/Severe	17 (55%)	35 (51%)	22 (79%)		52 (52%)	22 (79%)
Moderate-to-severe lesions
Absent/Mild	11 (35%)	28 (41%)	4 (14%)	0.04	39 (39%)	4 (14%)	0.01
Moderate/Severe	20 (65%)	41 (59%)	24 (86%)		61 (61%)	24 (86%)
OLGA
I-II	26 (84%)	60 (87%)	17 (61%)	0.119	86 (86%)	17 (61%)	0.003
III-IV	5 (16%)	9 (13%)	11 (39%)		14 (17%)	11 (39%)
OLGIM
I-II	20 (65%)	48 (70%)	13 (46%)	0.162	68 (68%)	13 (46%)	0.036
III-IV	11 (35%)	21 (30%)	15 (54%)		32 (32%)	15 (54%)

Lesions included atrophy or intestinal metaplasia; atrophy: atrophy located in any one biopsy; intestinal metaplasia: intestinal metaplasia located in any one biopsy; moderate-to-severe lesions: moderate to severe intestinal metaplasia, moderate to severe atrophy or low-grade intraepithelial neoplasia in any one location; CI: confidence interval