Table 1.
Mutations in QRDR genes in evolved, resistant P. aeruginosa, selected by ciprofloxacin
| Passage | Lineage1 | Lineage2 | Lineage3 | Lineage4 | Lineage5 | Lineage6 |
|---|---|---|---|---|---|---|
| 0. (0MIC) | – | – | – | – | – | – |
| 1. (1/2MIC) | – | – | – | – | – | – |
| 2. (1MIC) | – | A87 + B | A87 | – | – | – |
| 3. (2MIC) | A83 | A87 + B | A87 | – | – | – |
| 4. (4MIC) | A83 | A87 + B | A87 | A83 | – | A87* |
| 5. (8MIC) | A83 | A87 + B | A87 | A83 | – | A87* |
| 6. (16MIC) | A83 | A87 | A87 + B | A83 | / | / |
| 7. (32MIC) | A83 | / | / | A83 | / | / |
| 8. (64MIC) | A83 | / | / | A83 | / | / |
A83: gyrA83 (T83I; ACC → ATC); A87: gyrA87 (D87N; GAC → AAC); A87*: gyrA87 (D87G; GAC → GGC); B: gyrB466 (S466F; TCC → TTC)