Table 3.
Multilevel logistic regression to identify interactions between maternal prepregnancy BMI and subtypes of CHD in offspring a
| CHD subtype | Total cases, n | mOR (95%CI) in subgroups based on maternal prepregnancy BMI | |||||
|---|---|---|---|---|---|---|---|
| Subgroup cases, n | Underweight (BMI < 18.5) | Subgroup cases, n | Low average weight (18.5 ≤ BMI < 21.25) | Subgroup cases, n | Overweight (BMI ≥ 24.0) | ||
| SPD | 238 | 66 | 1.90 (1.11,3.26) | 107 | 1.63 (0.99,2.67)† | 15 | 0.96 (0.43,2.13) |
| VSD | 157 | 48 | 2.03 (1.06,3.88) | 70 | 1.46 (0.81,2.65) | 5 | 0.51 (0.16,1.62) |
| Otherb | 81 | 18 | 1.53 (0.66,3.52) | 37 | 1.58 (0.75,3.33) | 10 | 1.59 (0.56,4.52) |
| CTD | 255 | 62 | 1.23 (0.73,2.09) | 122 | 1.60 (1.01,2.53) | 17 | 0.83 (0.37,1.88) |
| LVOTO | 82 | 21 | 1.52 (0.66,3.54) | 37 | 1.40 (0.64,3.04) | 10 | 1.37 (0.45,4.20) |
| RVOTO | 81 | 24 | 1.75 (0.75,4.12) | 33 | 1.33 (0.60,2.93) | 7 | 1.83 (0.60,5.58) |
| AVR | 29 | 10 | 2.59 (0.69,9.73) | 12 | 1.87 (0.54,6.52) | 3 | 2.77 (0.53,14.30) |
| ELSE | 30 | 8 | 1.63 (0.47,5.71) | 15 | 0.88 (0.26,2.97) | 1 | 0.66 (0.07,6.15) |
SPD septal defect, VSD ventricular septal defect, CTD conotruncal defect, LVOTO left ventricular outflow tract obstruction, RVOTO right ventricular outflow tract obstruction, AVR anomalous venous return, ELSE other cardiac structure abnormalities. a Only cases with a single CHD were included. Odds ratios were adjusted for the factors shown in Table 1. Hospital was set as a random intercept effect. b Cases of the atrial septal defects (n = 21) and other septal defects excluding atrial septal defects (n = 60) were aggregated because of the small numbers of subjects. †p < 0.10