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. 2020 Jul 15;20(4):5. doi: 10.3892/ol.2020.11866

Figure 1.

Figure 1.

A total of two forms of nerve involvement in the PNI model in vivo. The sciatic nerve is located (A) superficial of the tumor tissue and (B) within the tumor tissue, providing evidence of PNI. Spatial association between sciatic nerve and tumor tissue, demonstrated by immunohistochemical staining of the pan-neuronal marker, PGP9.5. The sciatic nerve was located (C) superficial of or (D) within tumor tissue. The black arrow indicates the sciatic nerve; blue arrow indicates tumor tissue * indicates PGP9.5(+) nerve. PNI, perineural invasion.