Table III.
Top 5 Gene Ontology enrichment analysis of DEGs associated with PNI.
| A, Upregulated DEGs | ||
|---|---|---|
| Sub-ontology | Terms | P-value |
| MF | Calcium ion binding | 0.017056 |
| Transcription factor activity | 0.030121 | |
| β-tubulin binding | 0.036267 | |
| Protein heterodimerization activity | 0.041477 | |
| BP | Cilium morphogenesis | 0.028336 |
| Brown fat cell differentiation | 0.029846 | |
| Positive regulation of epithelial to mesenchymal transition | 0.031598 | |
| Cell death | 0.033012 | |
| Positive regulation of stress fiber assembly | 0.042919 | |
| B, Downregulated DEGs | ||
| MF | Heparin binding | 0.001728 |
| Receptor binding | 0.003766 | |
| Calcium ion binding | 0.005090 | |
| Chemoattractant activity | 0.005946 | |
| Steroid hormone receptor activity | 0.007413 | |
| BP | Chemotaxis | 6.15×10−6 |
| Cell-cell signaling | 9.42×10−6 | |
| Positive regulation of endothelial cell proliferation | 3.98×10−5 | |
| Positive regulation of mesenchymal cell proliferation | 0.000385 | |
| Skeletal system development | 0.000553 | |
| CC | Extracellular region | 1.51×10−8 |
| Extracellular space | 5.45×10−7 | |
| Proteinaceous extracellular matrix | 1.07×10−6 | |
| Integral component of plasma membrane | 1.96×10−6 | |
| Plasma membrane | 0.001295 | |
DEGs, differentially expressed genes; PNI, perineural invasion; MF, molecular function, BP, biological process; CC, Cellular component.