Table IV.
A total of eight KEGG pathways are associated with PNI.
| Regulation | ID | KEGG pathway | Gene count | P-value | Genes |
|---|---|---|---|---|---|
| Up | hsa04962 | Vasopressin-regulated water reabsorption | 3 | 0.044488 | DYNC1I1, CREB5, DYNC2H1 |
| Down | hsa03320 | PPAR signaling pathway | 5 | 0.012359 | MMP-1, PCK1, FABP3, CD36, ACOX2 |
| hsa05200 | Pathways in cancer | 12 | 0.015915 | CXCL12, GNGT1, FZD4, MMP-1, GLI1, AR, FLT3, IGF1, CTNNA2, GNG4, FGFR1, FGF2 | |
| hsa05144 | Malaria | 4 | 0.027847 | IL1B, HBB, CD36, KLRK1 | |
| hsa05323 | Rheumatoid arthritis | 5 | 0.030419 | IL1B, CXCL12, MMP-1, TEK, CCL20 | |
| hsa05032 | Morphine addiction | 5 | 0.033831 | PDE4D, GABRG2, PDE4B, GNGT1, GNG4 | |
| hsa04060 | Cytokine-cytokine receptor interaction | 8 | 0.034815 | IL1B, FLT3, CCL20, TNFSF9, CCR9, TNFRSF19, CCR5, CXCL12 | |
| hsa04062 | Chemokine signaling pathway | 7 | 0.038868 | CCR5, CXCL12, CCL20, CCR9, CCL15, GNGT1, GNG4 |
KEGG, Kyoto Encyclopedia of Genes and Genomes; PNI, perineural invasion; DEGs, differentially expressed genes.