Table 1.

Overview of perturbations applied to simulate multi-center data. Perturbation types and ranges vary with labels and MRI sequences according to the recommendation in [8]

Perturbation	Sequences	Segmentaion Labels	Perturbation assessment or range	Number of perturbations per sequence/label
Additivie Gaussian noise	All	–	Match SNR range	10 per sequence
Histogram binning	All	–	PyRadiomics recommended range (30–130 bins)	54 per sequence
Inter-rater simulation	–	All	Match Inter-rater DICE in [18]	10 per label
Voxel size	All	–	1–1.5 mm, isotropically	10 per sequence
Slice spacing	FLAIR, T2	–	1-4 mm, imaging recommendations in [8]	10 per sequence
	T1, T1c	–	1–1.5 mm, imaging recommendations in [8]	10 per sequence
K-space subsampling	All	–	Random subsampling, factor 0.8–1.0	21 per sequence