Table 3.

Association Between Drusen Size Progression, Genetic Susceptibility, and aMeDi Score

	Progressors	Nonprogressors
	Mean (SD)	Mean (SD)	HR (95% CI)*	P Value
Genetic Risk score†	1.06 (0.49)	0.81 (0.45)	2.68 (2.23–3.23)	<0.001
aMeDi Score	n (%)	n (%)
Low (0–3)	212 (21)	796 (79)	Ref
Medium–high (4–9)	375 (19)	1640 (81)	0.83 (0.68–0.99)	0.049

^*HRs calculated using Cox proportional hazards model adjusting for all covariates: age, sex, education, smoking, BMI, drusen size grade at baseline, total energy intake, AREDS treatment, multivitamin supplement use, genetic risk score (continuous), aMeDi score. For genetic score, HR is the change for a 1-unit increase. Eyes were used as the unit of analysis.

^†Gene score includes: 11 variants in 8 genes: CFH Y402H, CFH rs1410996, CFH R1210C, C2, C3 R102G, C3 K155Q, ARMS2/HTRA1 A69S, TIMP3, NPLOC4/TSPAN10, VEGFA and HSPH1/B3GALTL. Genetic risk score used as a continuous variable is based on the stepwise model presented in Table 2.

n (%) refers to the number of eyes.