Table 2.
Top 20 Upregulated and Top 20 Downregulated Protein-Coding Genes (P < 0.05) in Primary Human TM Cells in Response to Cyclic Mechanical Stretch (15%, 1 cycle/s, 24 h)
| Gene Symbol | Gene Name | Fold Change | P |
|---|---|---|---|
| TEFM | Transcription elongation factor, mitochondrial | 2187.24 | 3.45E-02 |
| IMMP1L | Mitochondrial inner membrane protease subunit 1 | 1778.30 | 4.05E-03 |
| UBE2C | Ubiquitin conjugating enzyme E2 C | 1693.36 | 3.12E-02 |
| TUBD1 | Tubulin, δ1 | 1531.26 | 2.40E-02 |
| RANBP3L | RAN binding protein 3 like | 1427.57 | 4.11E-02 |
| ADPRM | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase | 1241.30 | 2.80E-02 |
| TMEM81 | Transmembrane protein 81 | 1220.01 | 1.56E-02 |
| KDELC1 | Protein O-glucosyltransferase 2 | 968.60 | 3.61E-02 |
| DOK7 | Protein Dok-7 | 876.85 | 9.90E-03 |
| PTTG1 | Securin | 875.88 | 2.01E-02 |
| LTB4R2 | Leukotriene B4 receptor 2 | 749.49 | 2.81E-02 |
| NME6 | Nucleoside diphosphate kinase 6 | 745.65 | 3.30E-02 |
| GNA14 | Guanine nucleotide-binding protein subunit α-14 | 679.42 | 1.79E-02 |
| DENND6B | Protein DENND6B | 611.05 | 3.25E-02 |
| RAD51C | DNA repair RAD51 homolog 3 | 550.61 | 3.09E-02 |
| MYO1D | Unconventional myosin-Id | 547.27 | 2.93E-02 |
| TSSK2 | Testis-specific serine/threonine-protein kinase 2 | 487.53 | 1.32E-02 |
| GEMIN2 | Gem-associated protein 2 | 404.78 | 3.02E-02 |
| FAM69B | Divergent protein kinase domain 1B | 318.25 | 4.84E-03 |
| CLCN2 | Chloride voltage-gated channel 2 | 500.71 | 5.36E-03 |
| RBM3 | RNA-binding motif protein 3 | –2.78 | 1.44E-03 |
| RPS6KA5 | Ribosomal protein S6 kinase α-5 | –2.79 | 5.00E-02 |
| TTC30B | Tetratricopeptide repeat protein 30B | –2.79 | 4.22E-02 |
| OSGIN1 | Oxidative stress-induced growth inhibitor 1 | –2.84 | 3.04E-02 |
| SGCA | Alpha-sarcoglycan | –2.85 | 4.88E-02 |
| ATHL1 | Protein-glucosylgalactosylhydroxylysine glucosidase | –2.87 | 9.60E-03 |
| MAML3 | Mastermind-like protein 3 | –2.88 | 5.09E-03 |
| ARHGAP19 | Rho GTPase-activating protein 19 | –3.01 | 2.44E-03 |
| FBXO4 | F-box only protein 4 | –3.05 | 1.65E-02 |
| DUSP5 | Dual-specificity protein phosphatase 5 | –3.09 | 2.16E-02 |
| HIST1H4E | Histone H4 | –3.17 | 2.74E-03 |
| MTSS1 | Protein MTSS 1 | –3.19 | 2.07E-03 |
| HIST1H2AB | Histone H2A type 1-B/E | –3.25 | 4.13E-02 |
| KIAA1407 | Coiled-coil domain-containing protein 191 | –3.39 | 1.53E-02 |
| CRYL1 | Lambda-crystallin homolog | –3.54 | 2.92E-03 |
| TMEM91 | Transmembrane protein 91 | –3.61 | 3.24E-02 |
| TXNIP | Thioredoxin-interacting protein | –5.53 | 4.54E-03 |
| CXCL8 | Interleukin-8 | –7.44 | 4.80E-02 |
| TCEB3CL | Elongin-A3 member B | –7.87 | 3.13E-02 |
| RBM3 | RNA-binding protein 3 | –2.78 | 1.44E-03 |