Table 2.
Association of the Metastases/Extraocular Growth With Clinical Parameters and Adiponectin/Adipor1 Protein Levels (Follow-Up Time: 2–9 Years)
| All Patients | No Metastases | Metastases/Extraocular | ||
|---|---|---|---|---|
| (N = 26) | (N = 13) | Growth (N = 13) | P * | |
| Age at diagnosis, median (min, max) | 68 (39–83) | 67 (53–82) | 69 (39–83) | 0.51 |
| Sex, no. (%) | 0.85 | |||
| Female | 13 (50.0) | 6 (46.2) | 7 (53.9) | |
| Male | 13 (50.0) | 7 (53.9) | 6 (46.2) | |
| Eye, no. (%) | 0.56 | |||
| Right | 12 (46.2) | 7 (53.9) | 5 (38.5) | |
| Left | 14 (53.9) | 6 (46.2) | 8 (61.5) | |
| Tumor size in mm, median (min, max) | ||||
| Base 1 | 13.1 (1.4–18.6) | 12.2 (5.0–18.6) | 13.6 (1.4–17.5) | 0.63 |
| Base 2 | 13.0 (1.4–21.8) | 12.8 (6.0–21.8) | 14.4 (1.4–19.0) | 0.94 |
| Prominence | 7.7 (0.5–13.5) | 7.5 (0.5–12.9) | 8.2 (0.9–13.5) | 0.79 |
| Optic nerve invasion, no. (%) | 0.68 | |||
| No | 23 (88.5) | 12 (92.3) | 11 (84.6) | |
| Yes | 3 (11.5) | 1 (7.7) | 2 (15.4) | |
| Ciliary body invasion, no. (%) | ||||
| No | 24 (92.3) | 11 (84.6) | 13 (100) | 0.22 |
| Yes | 2 (7.7) | 2 (15.4) | 0 (0) | |
| Irradiation, no. (%) | 0.53 | |||
| No | 11 (42.3) | 4 (30.8) | 6 (46.2) | |
| Yes | 15 (57.7) | 9 (69.2) | 7 (53.9) | |
| CMC-positive, no. (%) | 0.22 | |||
| No | 2 (7.7) | 2 (15.4) | 0 (0) | |
| Yes | 24 (92.3) | 11 (84.6) | 13 (100) | |
| CMC-No. / 50 mL blood, median (min, max) | 8.2 (0-51) | 4 (0-51) | 10 (3.8-37.5) | 0.62 |
| M3 in CMC, No. (%) | 0.02 | |||
| No | 10 (38.5) | 8 (61.5) | 2 (15.4) | |
| Yes | 16 (61.5) | 5 (38.5) | 11 (84.6) | |
| % of CMC with M3, median (min, max) | 20.9 (0-100) | 0 (0-33.3) | 37.5 (11.8-100) | 0.00 |
| M3 in primary tumor, no. (%) | ||||
| Low | 8 (30.8) | 8 (61.5) | 0 (0.0) | 0.00 |
| Intermediate | 5 (19.2) | 3 (23.1) | 2 (15.4) | 0.74 |
| High | 13 (50.0) | 2 (15.4) | 11 (84.6) | 0.00 |
| Cytoplasmic BAP1 protein, no. (%) | 0.02 | |||
| High (grade 2+3) | 15 (60.0)† | 10 (83.3)† | 5 (38.5) | |
| Low (grade 0+1) | 10 (40.0) | 2 (16.7) | 8 (61.5) | |
| Nuclear BAP1 protein, no. (%) | 0.01 | |||
| High (grade 2+3) | 8 (32.0)† | 7 (58.3)† | 1 (7.7) | |
| Low (grade 0+1) | 17 (68.0) | 5 (41.7) | 12 (92.3) | |
| Adiponectin in primary tumor, median (min, max) | 52.8 (6.6-122.8) | 78.2 (6.6-122.8) | 46.8 (15.8-74.3) | 0.02 |
| Adipor1 in primary tumor, median (min, max) | 41.8 (4.8-64.0) | 52.2 (4.8-60.7) | 36.9 (15.3-64.0) | 0.04 |
CMC: Circulating melanoma cells; M3: Monosomy-3.
*
P values for the numerical variables and the proportions of the categorical variables were determined by the non-paired t-test and Barnard's exact test, respectively.
†
Data missing from one patient.