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. 2020 May 19;61(5):33. doi: 10.1167/iovs.61.5.33

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Figure 5. — Functional consequences and mechanism of ABCA1 agonist GW3965 treatment. (A) IOP was reduced by anterior chamber injection of GW3965 (100 µM, n = 5 mice in each group). (B) Western blot of ABCA1 signaling protein in outflow tissue (n = 4 eyes). (C) The relationship between outflow rate and IOP of GW3965 perfused mouse eyes. (D) A comparison of the C_con indicates markedly increased in GW3965 treated eyes compared with the vehicle treated eyes. *P < 0.05, **P < 0.01, ***P < 0.001, compared with vehicle-treated eyes. C1, blank; C2, vehicle control; C3, GW3965. A and C were analyzed using the paired-sample t-test. B (a-c) and D were analyzed using the Mann-Whitney U test.