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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Psychol Med. 2020 Jan 20;51(7):1147–1156. doi: 10.1017/S0033291719004045

Figure 1. Odds Ratios (OR) and 95% confidence interval for alcohol dependence diagnosis by PRS quartiles in ALSPAC, COGA, and UKB.

Figure 1.

PRS were split into quartiles and odds ratios calculated for case status for each quartile of risk compared to quartile 1 (lowest). A. Alcohol dependence in ALSPAC was coded by DSM-IV diagnosis (484 cases, 3,837 controls). B. Alcohol dependence was coded via DSM-IV diagnosis in the COGA sample (2,318 cases, 4,532 controls). C. A sample of European ancestry, unrelated British individuals who had ever drank, had ICD9 and ICD-10 codes available, and were not included in the discovery GWAS were used (4,141 cases, 241,806 controls).