Table 2. Associations between AUDIT-C and AUDIT-P PRS and multiple indices of alcohol use in COGA, UKB, ALSPAC and GS samples.
The PRS threshold (pT) that most strongly predicted each outcome (based on highest R2) is presented. Results significant at p < 0.0004 are bolded. Complete results are available in Supplemental Tables 1–12.
| AUDIT-C PRS | AUDIT-P PRS | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Outcome | Sample | pT | R2 | Beta (SE) | p-value | pT | R2 | Beta (SE) | p-value |
| Units per Week | GS | <0.1 | 0.27% | 0.052 (0.008) | 5.50E-11 | <0.01 | 0.15% | 0.039 (0.008) | 4.70E-07 |
| Alcohol use | COGA | <0.0001 | 0.32% | 0.129 (0.046) | 5.19E-03 | <0.4 | 0.65% | 0.188 (0.049) | 1.24E-04 |
| AUDIT-C | ALSPAC (age 23) | <0.1 | 0.59% | 0.066 (0.020) | 1.06E-03 | <0.01 | 0.65% | 0.067 (0.020) | 5.90E-04 |
| Max Drinks | ALSPAC | <0.5 | 1.54% | 0.389 (0.173) | 2.44E-02 | <0.2 | 3.26% | 0.540 (0.171) | 1.59E-03 |
| COGA | < 0.001 | 0.04% | 0.266 (0.147) | 7.03E-02 | < 0.2 | 0.47% | 0.879 (0.156) | 2.00E-08 | |
| CAGE | GS | <0.4 | 0.19% | 0.044 (0.010) | 8.60E-04 | <0.2 | 0.40% | 0.063 (0.010) | 9.00E-07 |
| AUDIT-P | ALSPAC (age 23) | <0.2 | 0.28% | 0.045 (0.020) | 2.61E-02 | <0.01 | 1.12% | 0.088 (0.020) | 9.05E-06 |
| Alcohol Dependence Symptom Count | ALSPAC (DSM-IV) | <0.3 | 0.84% | 0.091 (0.022) | 3.59E-05 | <0.01 | 0.84% | 0.086 (0.021) | 3.53E-05 |
| COGA (DSM-5) | < 0.1 | 0.08% | 0.103 (0.045) | 2.30E-02 | < 0.4 | 0.67% | 0.301 (0.046) | 1.01E-10 | |
| Alcohol Dependence | ALSPAC (DSM-IV) | <0.3 | 0.96% | 0.240 (0.052) | 4.81E-06 | <0.01 | 0.54% | 0.170 (0.050) | 5.75E-04 |
| COGA (DSM-IV) | <0.0001 | 0.14% | 0.078 (0.032) | 1.44E-02 | <0.4 | 0.68% | 0.199 (0.034) | 4.55E-09 | |
| UKB (ICD) | <0.0001 | 0.04% | 0.062 (0.016) | 8.90E-05 | <0.5 | 0.18% | 0.147 (0.020) | < 2.00E-16 | |