Table 2.

Strength of recommendation according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE)

Target audience	Strong	Weak (conditional)
Policymakers	The recommendation should be adopted as a healthcare policy in most of the situations.	Substantial debate required and the involvement of stakeholders.
Clinicians	Most of the individuals would want the intervention to be indicated, and only a small number would reject the recommendation.	A large portion of the individuals would want the intervention to be indicated; however, some individuals would reject the recommendation.
Patients	Most of the patients should receive the recommended intervention.	The clinician should acknowledge that different choices are appropriate for each patient and choose consistently with his/her values and preferences.

Source: Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group. Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach. Updated October 2013. Available from: https://gdt.gradepro.org/app/handbook/handbook.html.⁽¹⁹⁾