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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Nat Med. 2020 Apr 13;26(5):769–780. doi: 10.1038/s41591-020-0815-6

Extended Data Figure 10. M4 Astrocyte/Microglial Metabolism Module Members Increased at the Transcript Level in Microglia Undergoing Active Amyloid-β Plaque Phagocytosis.

Extended Data Figure 10.

mRNA transcripts increased in microglia undergoing active amyloid-β plaque phagocytosis (XO4+)33 were overlapped with cognate proteins in the M4 module. There were 23 transcripts that overlapped with M4 module members. Proteins that also overlapped with the top 30 disease-associated microglia (DAM) markers in the M4 module (Figure 5D) are shown in blue. Proteins that did not overlap with the top 30 DAM markers are shown in cyan. Proteins in cyan are therefore M4 members that may be more specifically elevated in microglia undergoing active amyloid-β plaque phagocytosis.