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. Author manuscript; available in PMC: 2020 Aug 5.
Published in final edited form as: Drug Discov Today. 2019 Jan 17;24(3):873–882. doi: 10.1016/j.drudis.2019.01.006

Figure 2.

Figure 2.

(a) Transmission electron microscope (TEM) images of amyloid-β aggregates decorated with LPFFD-grafted IONPs before and after 3 h exposure to an alternating magnetic field (AMF). Disaggregation of amyloid-β aggregates was observed after local heating. Reproduced, with permission, from [38]. (b) DNA damage assessment for animals after treatment with (i) 5% glucose, (ii) polymer nanoparticles containing IONPs, siTGF-β and TMZ (LBTA), and (iii) LBTA functionalized with angiopep-2 (ALBTA). (iv) Relative γH2A.X foci number in tumor. (c) In vivo T2*-weighted MRI images of brains in intracranial glioblastoma mice before and after injection of LBTA and ALBTA. Reproduced, with permission, from [63].