Table 3.

Cross-Sectional Multivariable Analysis of Determinants of VRQoL

	Coefficient	95% Confidence Interval
Best-corrected visual acuity (better eye)	–10.72	–15.24 to 91.95
Best-corrected visual acuity (worse eye)	–9.63	–169.56 to –6.20
Square root transformed geographic atrophy area (better eye)	–3.50	–7.76 to –1.35
Low-luminance visual acuity (better eye)	–9.71	–312.18 to –9.37
Low-luminance visual acuity (worse eye)	–0.34	2.91 to 443.50
Foveal sparing (worse eye)	–8.13	–18.96 to –1.32

LASSO regression was applied for variable selection and shrinkage of coefficient estimates. The selected biomarkers are listed with their coefficient obtained from the LASSO and the corresponding 95% confidence interval.