Table 1.
Demographic and clinical data of patients with stroke possibly related and unrelated to COVID-19. COVID-19 indicates Coronavirus Disease 19; SD, standard deviation; IQR, interquartile range; ICU, intensive care unit; NIHSS, National Institutes of Health Stroke Scale; iv-tPA, intravenous tissue-type plasminogen activator; EVT, endovascular treatment.
| All stroke (N = 25) | Stroke unknown/infrequent etiology (N = 9) | Stroke known etiology (N = 16) | p value | |
|---|---|---|---|---|
| Age (mean, SD) | 66.5 (15.2) | 56.6 (17.3) | 72.1 (10.7) | 0.01 |
| Gender (male) | 14 (56.0%) | 4 (44.4%) | 10 (62.5%) | 0.38 |
| prestroke mRS (median, IQR) | 1 (0-2) | 0 (0-1) | 1 (0-2) | 0.22 |
| Vascular risk factors | ||||
|---|---|---|---|---|
| Hypertension | 14 (56.0%) | 5 (55.6%) | 9 (56.3%) | 0.97 |
| Diabetes mellitus | 9 (36.0%) | 3 (33.3%) | 6 (37.5%) | 0.83 |
| Hyperlipidemia | 11 (44.0%) | 3 (33.3%) | 8 (50.0%) | 0.42 |
| Current smoker | 8 (32.0%) | 3 (33.3%) | 5 (31.3%) | 0.92 |
| Atrial fibrillation | 4 (16.0%) | 0 | 4 (25.0%) | 0.1 |
| Obesity | 6 (24.0%) | 3 (33.3%) | 3 (18.8%) | 0.41 |
| COVID-19 infection | ||||
|---|---|---|---|---|
| Prestroke symptoms | 17 (68.0%) | 9 (100%) | 8 (50%) | 0.02 |
| Days of evolution (mean, SD) | 12 (7.5) | 14.9 (8.4) | 9.4 (5.9) | 0.14 |
| ICU admission | 8 (32.0%) | 6 (66.7%) | 2 (12.5%) | 0.02 |
| Severe infection | 14 (56.0%) | 9 (100%) | 6 (37.5%) | 0.01 |
| Stroke | ||||
|---|---|---|---|---|
| NIHSS (median, IQR) | 168, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 | 106, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26 | 169, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 | 0.82 |
| Unknown onset | 14 (56.0%) | 6 (66.7%) | 8 (50.0%) | 0.52 |
| Ischemic stroke | 21 (84.0%) | 9 (100%) | 12 (75.0%) | 0.10 |
| Intracranial hemorrhage | 4 (16.0%) | 0 | 4 (25.0%) | 0.10 |
| iv-tPA | 5 (20.0%) | 2 (22.2%) | 3 (18.8%) | 0.84 |
| EVT | 10 (40.0%) | 4 (44.4%) | 6 (37.5%) | 0.61 |