Figure 4.

Eosinophil Changes from Admission to Recovery

2D representation generated by partition-based graph abstraction (PAGA) of eosinophils from patient COV-40 at 7 different time points from admission to recovery.

(A and B) Louvain clusters are colored and annotated by key protein characteristics (A), and cell distributions at each individual time point indicate changes in immune cell states and composition over time (B).

(C) Plasma IFN-γ levels as measured by Olink assay in plasma samples from patient COV-40.

(D) IFN-γ-mediated upregulation of CD62L contributes to lung inflammation hyperinflammation.