Figure 6.

Cell-Cell Communications Network during Different Phases from Acute to Recovery of COVID-19

(A) Spearman correlation matrices from 35 patients, with samples collected at the indicated time intervals and ordered by top correlations. Co-regulated cell populations are highlighted by boxes.

(B) Serum IgG antibodies against SARS-CoV-2 Spike protein receptor-binding domain (RBD) from 17 acute patients. RBD showed against days after admission.

(C) Mixed-effects modeling (MEM) of plasma protein levels and immune cell population frequencies against anti-RBD IgG titers. The 5 most positively and negatively associated features in MEM are correlated with antibody responses when days from admission is taken into account as a fixed effect.