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(a) Crystal structure of FisCP (accession number: AMW32563, PDB ID: 5E3X); (b) The active sites of FisCP (His253-Glu254-His257-Glu283 (Co2+)) are displayed as sticks; (c) The mechanism of catalyzing the hydrolysis of protein by FisCP: deprotonation of the nucleophilic water molecule; nucleophilic attack of the resulting hydroxide on the scissile carbonyl carbon; protonation of the scissile amide group, followed by cleavage of the peptide bond (Szeto et al., 2009).
