Table 2.
Reactome pathway overrepresented in positive samples.
| Reactome pathway | ||||||
|---|---|---|---|---|---|---|
| Homo sapiens (REF) | Input (proteins overrepresented in positive samples) |
|||||
| #* | #⁎⁎ | Expected⁎⁎⁎ | Fold enrichment | +/- | Raw p-value |
|
| SRP-dependent cotranslational protein targeting to membrane | 112 | 17 | 0.53 | 31.97 | + | 6.62E-17 |
| Viral mRNA Translation | 89 | 15 | 0.42 | 35.50 | + | 3.04E-15 |
| Peptide chain elongation | 89 | 15 | 0.42 | 35.50 | + | 3.04E-15 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 115 | 16 | 0.55 | 29.30 | + | 3.21E-15 |
| Selenocysteine synthesis | 93 | 15 | 0.44 | 33.97 | + | 5.94E-15 |
| Eukaryotic Translation Termination | 93 | 15 | 0.44 | 33.97 | + | 5.94E-15 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 95 | 15 | 0.45 | 33.97 | + | 7.31E-15 |
| Formation of a pool of free 40S subunits | 101 | 15 | 0.48 | 31.28 | + | 1.67E-14 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 101 | 15 | 0.48 | 31.28 | + | 1.67E-14 |
| Regulation of expression of SLITs and ROBOs | 169 | 17 | 0.80 | 21.19 | + | 3.82E-14 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 111 | 15 | 0.53 | 28.46 | + | 6.03E-14 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 112 | 15 | 0.53 | 28.21 | + | 6.81E-14 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 182 | 15 | 0.86 | 17.36 | + | 5.18E-11 |
| Formation of the ternary complex, and subsequently, the 43S complex | 51 | 7 | 0.24 | 28.91 | + | 2.17E-05 |
| Ribosomal scanning and start codon recognition | 58 | 7 | 0.28 | 25.42 | + | 4.88E-05 |
| Translation initiation complex formation | 58 | 7 | 0.28 | 25.42 | + | 4.88E-05 |
| Mitochondrialproteinimport | 65 | 6 | 0.31 | 19.44 | + | 2.21E-03 |
| Interferon gamma signaling | 91 | 6 | 0.43 | 13.89 | + | 1.38E-02 |
| Downstream TCR signaling | 102 | 6 | 0.48 | 12.39 | + | 2.56E-02 |
⁎
All genes from H. sapiens were used as comparative dataset.
⁎⁎
The number of proteins found in the input dataset that were assigned to the corresponding biological process.
⁎⁎⁎
This column represents the expected number of H. sapiens genes according to the size of dataset used as an input. The input dataset was all proteins incremented in positive samples when compared to negative samples. Fisher exact was used as statistical analysis with Bonferroni correction for multiple testing. Biological processes are ordered according to the p-value. Pathways with less than 5 proteins found in the input dataset were not considered.