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. Author manuscript; available in PMC: 2020 Aug 5.
Published in final edited form as: Cell Rep. 2015 Mar 5;10(9):1599–1613. doi: 10.1016/j.celrep.2015.02.014

Figure 6. Errfi1, a Negative Regulator of ErbB2 Signaling, Plays Critical Roles in Tumor Progression in the Pten-Null Background.

Figure 6.

(A and B) Quantitative real-time PCR (A) and WB (B) analyses of Errfi1 expression level in mouse lungs and lung tumors.

(C and D) WB (C) and IHC (D) analyses of p-ERBB2/ERBB2 and p-AKT/AKT signaling in 9-month-old mouse lungs.

(E and F) Primary lung tumors were observed in the Errfi1d/dPtend/d mouse lungs. (E) The primary lung tumors are indicated by black arrows. (F) Summary of Errfi1d/dPtend/d mice with frequency of lung tumor.